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India’s space sector created 22,000 job in last decade, positively contributed to economy: study

The study noted that the number of homegrown space startups in India surged from 1 in 2014 to 229 by mid-2024.

A marked increase in homegrown space startups, industries manufacturing space-qualified products, and a growing reliance on satellite-based services have all positively impacted India’s economy, a new study has found. It also said the space sector has contributed to the country’s employment and overall social development.

The study, titled ‘Space economy of India, its impact on the rest of the economy’, published in the journal Space Policy enlisted the creation of around 22,000 new jobs in this sector in the past decade.

In 2020–21, the space sector contributed a modest 0.19 per cent of India’s Gross Domestic Product (GDP), but this share has been rising, as per the study. Monetarily, the New Space India Limited (NSIL), the commercial arm of the Indian Space Research Organisation (ISRO), generated a revenue worth Rs 2,940 crore in 2022-2023, the study noted.

The year-on-year increment in the revenue is estimated to remain around 24 per cent, said the study authored by experts from the Indian Institute of Space Science and Technology, Thiruvananthapuram; Centre for Development Studies, Thiruvananthapuram; Ahmedabad University and National Institute of Advanced Studies, Bengaluru.

Policy-level changes with the introduction of Space Activities Policy 2023 and the establishment of the Indian National Space Promotion and Authorisation Centre (In-SPACe), too, created a positive shift in the way the space economy has shaped in recent years, according to the study.

According to the study, with more countries turning into private players for venturing into space, employment generation holds potential even in India.

“Private space startups are attracting substantial investments, generating revenue through satellite manufacturing, launch services and space-based applications. Sectors like telecommunications, agriculture and navigation have benefited from satellite services, enhancing their operational efficiency and productivity,” said the study.

In India, the number of homebred space startups went from one to 229 from 2014 mid-2024, and they are believed to employ about 2,500 people at present.

ISRO has remained the primary driver of space-related activities in India and the space agency directly employs over 17,000 people. The overall employment covering the broader space industry is estimated to be 45,000–50,000.

India’s space economy covers manufacturing, operations and applications. The space manufacturing segment includes the production of launch vehicles, satellites, spacecraft subsystems, scientific instruments and ground equipment.

Space operations encompass launch services, satellite operation and brokerage, ground station management, in-orbit servicing, space surveillance, debris removal, space tourism, in-space manufacturing and the operation of spaceports. Space applications cover services like direct-to-home broadcasting, satellite communications, location-based services, satellite data processing and downstream applications using satellite signals.

According to the study, some of the key emerging areas in this sector include deep exploration missions, greater involvement of private players and international collaborations.

Even with modest spending with respect to the country’s GDP, the space sector holds immense potential and far-reaching and multi-sectoral reach, the study said. Improvements brought through satellite-based services and geographical information services-based tools are immensely benefitting sectors like agriculture, disaster management, national security, weather forecasting, urban planning, energy planning, navigation, infrastructure development, land management and more, it said.

The researchers said the technological innovations and spillovers to sectors also added to the overall contribution to the economy.

source/content: indianexpress.com (headline edited)

India carries out test of advanced underwater naval mine

The MIGM is designed to enhance the Indian Navy’s capabilities against modern stealth ships and submarines.

India has successfully test-fired an advanced underwater naval mine designed to enhance the Navy’s capabilities against modern stealth ships and submarines.

The development came amid increasing tensions between India and Pakistan over the Pahalgam terror attack.

“The Defence Research and Development Organisation (DRDO) and Indian Navy have successfully undertaken combat firing (with reduced explosive) of the indigenously designed and developed Multi-Influence Ground Mine (MIGM),” the defence ministry said on Monday (May 5, 2025).

It said the the system is an advanced underwater naval mine developed by the Naval Science and Technological Laboratory, Visakhapatnam in collaboration with other DRDO laboratories.

The MIGM is designed to enhance the Indian Navy’s capabilities against modern stealth ships and submarines. Bharat Dynamics Limited, Visakhapatnam and Apollo Microsystems Limited, Hyderabad are the production partners for the system.

Complimenting DRDO, Indian Navy and the Industry, Defence Minister Rajnath Singh said the system will further enhance undersea warfare capabilities of the Indian Navy.

source/content: thehindu.com (headline edited)

ICAR marks a first, develops two genome-edited varieties of rice

Union Minister of Agriculture and Farmers’ Welfare Shivraj Singh Chouhan released the two rice varieties at the ICAR’s NASC Complex on Sunday.

The Indian Council of Agricultural Research (ICAR) said it has developed the world’s first genome edited (GE) rice varieties with superior yields, drought and salinity tolerance, and high nitrogen-use efficiency traits.

Two of its affiliate institutions — the Hyderabad-based Indian Institute of Rice Research (IIRR) and the Indian Agricultural Research Institute (IARI) at New Delhi — have bred improved GE mutants of the popular Samba Mahsuri (BPT-5204) and Cottondora Sannalu (MTU-1010) varieties using CRISPR-Cas SDN-1 (Site-Directed Nucleases-1) technologies.

Union Minister of Agriculture and Farmers’ Welfare Shivraj Singh Chouhan released the two rice varieties at the ICAR’s NASC Complex on Sunday.

    GE is different from genetic modification or GM. The latter involves introduction of genes from unrelated species into host plants.

    The Indian Council of Agricultural Research (ICAR) said it has developed the world’s first genome edited (GE) rice varieties with superior yields, drought and salinity tolerance, and high nitrogen-use efficiency traits.

    Two of its affiliate institutions — the Hyderabad-based Indian Institute of Rice Research (IIRR) and the Indian Agricultural Research Institute (IARI) at New Delhi — have bred improved GE mutants of the popular Samba Mahsuri (BPT-5204) and Cottondora Sannalu (MTU-1010) varieties using CRISPR-Cas SDN-1 (Site-Directed Nucleases-1) technologies.

    Union Minister of Agriculture and Farmers’ Welfare Shivraj Singh Chouhan released the two rice varieties at the ICAR’s NASC Complex on Sunday.

    GE is different from genetic modification or GM. The latter involves introduction of genes from unrelated species into host plants. These could, for example, be genes from Bacillus thuringiensis, a soil bacterium, that code for the production of proteins toxic to various insect pests in cotton.

    CRISPR-Cas uses ‘Cas’ enzymes, or proteins that act like molecular “scissors”, to cut and modify the DNA sequence of a native gene at its targeted location. Such editing is intended to bring forth desirable alterations in that gene’s expression and function.

    In this case, scientists at IIRR have used the CRISPR-Cas12 protein for editing the ‘cytokinin oxidase 2’ gene (also called Gn1a) in Samba Mahsuri rice, in order to the increase the number of grains produced from each panicle (plant earhead) of this variety.

    The Gn1a gene basically codes for an enzyme that regulates the number of grains per panicle, thereby indirectly influencing yields. Through “editing”, the scientists are able to reduce the expression of that gene, leading to an increase in the number of grains per plant.

    The Samba Mahsuri rice variety is extensively cultivated in about five million hectares (mh) across Tamil Nadu, Andhra Pradesh, Telangana, Karnataka, Odisha, Chhattisgarh, West Bengal, Bihar, Jharkhand and eastern Uttar Pradesh.

    The new GE line – called IET-32072 or ‘Kamala’ – is claimed to have recorded an average paddy (rice with husk) yield of 5.37 tonnes per hectare with a potential of 9 tonnes. This is higher than the corresponding average and potential yields of 4.5 tonnes and 6.5 tonnes/hectare from its parent Samba Mahsuri (BPT-5204) variety.

    Further, ‘Kamala’ matures in about 130 days (from seed to grain), 15-20 days earlier than Samba Mahsuri, but has the same grain attributes and cooking quality “exactly like the original variety”, according to an ICAR statement.

    The CRISPR-Cas9 protein has been used similarly to edit the ‘DST (drought and salt tolerance)’ gene in the MTU-1010 or Cottondora Sannalu rice variety, which is grown in 4 mh across southern, central and eastern India. The variety is popular for its high yields (potential of 7 tonnes/hectare), early duration (125-130 days), and producing long slender grains.

    The new GE mutant of MTU-1010 will enable this variety to also be cultivated in areas prone to drought and salinity stress.

    The GE SDN-1 mutant line – called IET-32043 or Pusa DST Rice 1 – is claimed to have recorded an average paddy yield of 3.508 tonnes/hectare under inland salinity stress conditions, compared to 3.199 tonnes of the parent (MTU-1010) variety).

    It has also given an average of 3.731 tonnes/hectare under alkaline and 2.493 tonnes/hectare under coastal stress conditions, as against the corresponding yields of 3.254 tonnes and 1.912 tonnes per hectare respectively.

    India has exempted GE crops from biosafety regulations under the Environment (Protection) Act of 1986. These regulations govern both field trials and release for commercial cultivation in the case of GM crops that are treated as “hazardous substances” under the Act.

    The GE mutants created through SDN-1 and SDN-2 techniques are free of foreign genes or exogenous DNA. Their “release” into the environment is, hence, seen to not pose risks and require multi-year trials and approvals, if at all, from the Genetic Engineering Appraisal Committee under the Ministry of Environment, Forest and Climate Change.

    Both the improved GE varieties were tested in multi-location field trials under the All India Coordinated Research Project on Rice during 2023 and 2024. This followed the approval from the Department of Biotechnology’s Review Committee on Genetic Manipulation to consider these as “free of exogenous introduced DNA” and “equivalent to conventional mutant/breeding lines”.

    The ICAR statement said that the development of the two GE rice varieties has paved the way for using this technology for higher yields, climate resilience, and improved quality traits in oilseeds, pulses and other crops too. The 2023-24 Union Budget had allocated Rs 500 crore for GE breeding and research in agriculture.

    The statement conceded there are still issues over intellectual property rights on the CRISPR-Cas9 technology, which is patented by the Broad Institute of MIT and Harvard. Its use is licensed. The IPR concerns “are being looked after and will be resolved in coming times,” ICAR said.

    source/content: indianexpress.com (headline edited)

    New pinch. Only 140-Rice varieties exist in West Bengal today

    Less than a century ago, 15,000 varieties of rice were cultivated in Bengal; now 140 remain. The new grains that have elbowed out the old ones have upset an entire food system.

    The word nabanna means “new rice” in Bengali and usually refers to the harvest festival celebrating the aman dhaan or kharif crop harvested in November and December. Nababarsha refers to the Bengali New Year, which is celebrated in April. When these concepts — nabanna and nababarsha — were coined, there was no way of yoking the two. But, like much else in this topsy-turvy world, it is now a reality. It is also true that the new year in peak summer marks the start of the boro harvest, the actual nabanna.

    Boro dhaan is harvested right through Baisakh (mid-April to mid-May),” says Rafikul Alam Sahana, who cultivates rice in Katwa in East Burdwan district, which is also known as the rice bowl of West Bengal.

    Boro paddy is a comparatively recent phenomenon. “This fertiliser and water-intensive boro paddy cultivation we see now with modern, high-yielding seeds happened because of the Green Revolution,” says Anupam Pal, who is a rice scientist and a former state government employee.

    Boro dhaan was popularised in Bengal in the 1970s. Before that, the January to March growing season was used to cultivate pulses, mustard, sesame, potatoes and onions. “Some paddy was also cultivated near water bodies. Varieties such as kala boro, lal boro, lathishal. There was also guligati, the deep water boro paddy that is now extinct,” says Pal. The paddy was irrigated with a dong, a boat-shaped device that scooped out water from ponds or rivers and poured it onto the fields. There was very little land suited to boro paddy cultivation, Pal adds.

    Robin Bannerjee has been working with farmers for three decades, trying to convince them to return to the traditional way of farming. He says that lal boro and kala boro used to be grown in standing water. “Boro dhaan used to be cultivated in marshy areas or alongside the G.T. Road in Hooghly and Burdwan districts, where the water for cultivation came from the nayanjuli or canal running parallel to the highway,” says Bannerjee.

    Before the Green Revolution, a total of 1,10,000 native varieties of rice were cultivated in India, noted eminent rice scientist R.H. Richharia. An estimated 15,000 varieties are reported to have been cultivated in undivided Bengal alone in the 1940s. The recorded number of landraces — traditional crop varieties — cultivated before the1970s in West Bengal was 5,556, while across the border the Bangladesh Rice Research Institute recorded 12,479 names. Now, most of the rice cultivated across India is limited to 10 high-yielding modern varieties.

    Native seeds produced 3 tonnes of crop per hectare, whereas high-yielding varieties produce 8-9 tonnes in optimum conditions. The advertised high yield of the latter led to its popularity, piggybacking on the memories of the 1943 Bengal famine.

    Says Bannerjee, “There was severe drought in north Bihar in the early 1960s. That was used by America to fan the fear of famine and influence India into buying these modern seeds they were marketing.”

    These new seeds actually needed much more water than native varieties and farmers had to install pumps to access groundwater for irrigation. That apart, the farmer had to buy chemical fertiliser by the sack, pesticides and, of course, the seeds themselves. “While for native rice, farmers woulduse seeds from the previous year, the modern seedshad to be bought,” explains Bannerjee. In the traditional method, fish and crabs would spawn inthe standing water in paddyfields, which farm labourers were free to catch to supplement their diet and barter for foodstuff they could not afford.

    The high-yielding seeds can be used for three crop cycles, but the yield reduces with each cycle and after three years, they must be replaced. For hybrid crops, new seeds have to be planted each year. According to experts, these seeds need to be immersed in pesticide before planting. While it makes the paddy immune to certain pests, it also kills all plants and animals in the fields.

    Why did the farmer adopt a style of agriculture so different to the traditional one? “Because the government pushed it, and they had faith in the government, because they wanted to produce more, because they aspired to a better lifestyle,” says a farmer, who is trying to popularise organic farming in the Sunderbans; he does not want to be identified. What remains unsaid isthat the farmers had no idea of the side effects.

    “People do not treat Earth as their mother anymore. They do not treat fellow creatures as their brothers. They have become self-centred. They only think of themselves, of their own profit. Farmers are no different,” says Sukumar Sarkar, who calls himself a socio-political worker who works in the area of food, food as nutrition, food as medicine. He grows basmati rice the traditional way in Jaunpur, Uttar Pradesh. He calls it cow-based farming. “It is an interdependent cycle. You need cows to fertilise fields, hens and ducks to eat up pests. Farmers must keep livestock too,” he says while drawing attention to the fact that while a kilo of fertiliser could on an average grow 14 kilos of rice at the beginning of the Green Revolution, it grows only 3 kilos now.

    “The average yield of rice in India in recent years is nearly 3 tonnes per hectare,” says Pal, which is the same as from traditional seeds.

    In Bengal, about 140 varieties of traditional rice are still cultivated. However, more than 90 per cent of the landraces grown in the state even half a century ago are lost. The loss, writes Debal Deb in his 2021 paper titled Rice Cultures of Bengal, leads to derangement of local food cultures, and food insecurity for poor and marginal farmers, not to speak of the erasure of a vast body of knowledge. He goes on about how this has also “disintegrated the communitarian ethos among Bengali farmers”.

    If paddy seed is not sown for two consecutive years, it spoils. No matter what gene banks claim, the only way to preserve these varieties is to grow them every year, says India’s rice conservationist Deb. In his 1.7 hectare farm near the Niyamgiri hills in Odisha, Deb keeps alive nearly 1,500 varieties of native seeds by cultivating them every year. It takes him a dozen days to make a planting plan such that each seed will flower at a different time so there is no cross-pollination.

    Deb does not sell the seeds he preserves. Just like in olden times, he exchanges a kilo of one seed with a kilo of another traditional seed. If the farmer has no seeds to offer, he can return two kilos of the grain he grows using these seeds.

    India produced a record paddy crop of 1,378 lakh metric tonnes in 2024, according to government data. West Bengal slipped from top spot to fourth place. The wheat crop too was satisfyingly large, yet India has to import wheat. More to the point, last year India was 105 on the World Global Hunger Index among 127 countries.

    “The hunger index measures hunger by nutrition and we are a malnourished country,” says Pal. The first culprit, he says, is the milled rice we eat. “The bran, which has all the nutrients, is polished away in rice mills, leaving just the carbohydrate-rich grain. It might fill the stomach but cannot nourish,” he adds.

    Deb has been working on decoding the nutrient value of traditional rice. He has found varieties rich in iron, zinc, antioxidants, even silver. The grain with traces of silver is called garibsal or poor man’s rice. Unlike Manila’s International Rice Research Institute-promoted genetically modified iron-fortified rice, which they claim has 8.9mg of iron per kilo, the 68 native varieties Deb and his team have documented contain up to 350mg of iron per kilo of rice.

    Deb has also identified a strain of rice that has the essential fatty acids found only in mother’s milk, which are required for brain development. He has identified 15 native varieties of rice that give a better yield than high-yielding seeds do in optimum conditions. And they do not need expensive chemical fertiliser.

    Whether you call it organic farming, cow-based farming or traditional farming, the truth remains that the only way forward is going back.

    source/content: telegraphindia.com (headline edited)

    UoH faculty member elected as Fellow of Royal Society of Chemistry

    G.S. Vaitheeswaran from University of Hyderabad’s (UoH) School of Physics has been elected as a Fellow of the prestigious Royal Society of Chemistry for his contributions to understanding the electronic structure of solids, particularly in the field of energetic materials.

    The fellowship will enable Prof Vaitheeswaran to expand his research network and collaborations with universities worldwide, facilitating international funding and participation in conferences.

    He has received several notable awards, including the DAE Young Achiever Award, B.M. Birla Science Prize in Physics, and the Chancellor Award for Excellence in Teaching and Research, as per a press release on Friday (May 1, 2025).

    source/content: thehindu.com (headline edited)

    India retains 4th rank in optimism, 6 of 10 citizens believe country is moving in right direction: Survey

    Inflation remains key concern as global south shows higher confidence in future.

    In the latest April wave of the Ipsos What Worries the World survey, India has retained its 4th position in global optimism, with 62% of Indian citizens expressing hope for a better future. The data reflects continued positivity in India, matching results from the previous wave, and highlights the growing confidence in several global south markets.

    India is joined at the top by fellow Asia-Pacific Economic Cooperation (APEC) countries, with Singapore (85%) leading the pack, followed by Malaysia (70%), Indonesia (67%), India (62%), and Thailand (55%). Argentina also featured strongly, tying with Thailand at 55%.

    Amit Adarkar, CEO of Ipsos India, provided insight into the findings, emphasizing India’s strategic position and internal strengths. “We have the global advantage of being geographically away from both Ukraine and Gaza, the epicentres of wars. India and the other global south markets have largely been driven by domestic consumption and domestic economy. And India also has the demographic dividend, leading to economic growth.”

    He added, however, that emerging challenges were not yet reflected in this survey wave. “This survey was conducted before the Trump tariffs were announced (with a 90 day pause to reciprocal tariff) and before the Pahalgam terror strike took place. These events have heightened anxiety and fear among citizens which have not been captured in the current wave. India being a strong economy and a resilient market, it will continue to stay on grid. But the unrest at the borders and the looming reciprocal tariffs by the Trump govt could lead to a strong impact on India’s fortunes.”

    Despite the buoyant outlook among the global south, the report reveals rising global pessimism, particularly in countries such as Peru, South Korea, and France. These nations showed a more negative outlook about the future, in stark contrast to the optimism seen across much of Asia and Latin America.

    One key finding from the survey is the prominence of inflation as the top issue globally and within India. According to Adarkar, “Ipsos’ What Worries the World survey tracks public opinion on the most important social and political issues across 29 countries today. And inflation continues to impact both global and local citizens with high cost of living, as a consequence of global economic slowdown, wars in Gaza and Ukraine and now with tough measures by the Trump regime on the anvil, in terms of job cuts and reciprocal tariffs, we are bracing for tougher times ahead.”

    He further stated, “With the terror strike in Pahalgam and India’s tough call, the citizens are likely to bear the brunt of these new developments, with increase in prices of essential commodities and slowdown in inbound travel of foreign tourists, impacting the economy.”

    Adarkar concluded with a recommendation for policymakers: “Govts should focus on their local worries to provide reprieve to citizens, as these concerns weigh heavily on them.”

    Survey Methodology

    The 29-country Global Advisor survey was conducted between March 21 and April 4, 2025, via the Ipsos Online Panel system, polling 25,219 adults aged between 16 and 74, depending on country-specific ranges. In India, around 2,200 individuals were surveyed, with approximately 1,800 face-to-face interviews and 400 online.

    The sample in India represents the urban population, including socio-economic classes A, B, and C across metros and Tier 1–3 towns. The findings were weighted to reflect recent census demographics and are indicative of the views of India’s more connected population segment.

    Ipsos, one of the world’s largest market research companies, operates in 90 markets with over 20,000 employees, offering insights into global opinions, behaviours, and trends.

    source/content: indianexpress.com (headline edited)

    World’s largest fusion project reaches construction milestone with India’s help

    India is among the seven main members of the project and has played a key role in building some of its most critical infrastructure.

    In a major milestone, scientists working on the world’s largest nuclear fusion project have completed its main magnet system with India playing a key role in building critical infrastructure.

    This system will power the core of ITER (International Thermonuclear Experimental Reactor) Tokamak reactor, which aims to demonstrate that fusion, the energy source of the sun and stars, can be used as a safe and carbon-free power source on Earth.

    Unlike nuclear fission, which splits atoms and produces radioactive waste, fusion involves heating hydrogen gas to extremely high temperatures until the atoms fuse, releasing large amounts of energy sans nuclear waste.

    India is among the seven main members of the project and has played a key role in building some of its most critical infrastructure, including the massive cryostat cooling systems and heating technologies.

    The final part of the magnet system was the sixth module of the Central Solenoid, the main magnet that will drive plasma, the superhot gas in which fusion reactions take place, in the reactor.

    Built and tested in the United States, this powerful magnet will soon be assembled at the ITER site in southern France. When complete, it will be strong enough to lift an aircraft carrier and form the electromagnetic heart of the doughnut-shaped fusion machine.

    ITER, which stands for International Thermonuclear Experimental Reactor, is a joint scientific effort of more than 30 countries, including India, China, the US, Russia, Japan, South Korea and members of the European Union.

    The goal is to prove that fusion energy can be produced at an industrial scale.

    The magnet system just completed is critical to creating and controlling the ultra-hot plasma inside the reactor. At full power, ITER is expected to produce 500 megawatts of energy from just 50 megawatts of input.

    This would make the plasma self-sustaining, a state known as “burning plasma”, which scientists see as key to unlocking fusion energy.

    India has designed and manufactured the cryostat, an enormous 30-metre tall and 30-metre wide chamber that houses the entire ITER Tokamak.

    India has also built the cryolines that carry liquid helium to cool the magnets to minus 269 degrees Celsius, the temperature needed for superconductivity.

    It has also delivered the reactor’s in-wall shielding, cooling water systems and key parts of the heating systems that will raise the temperature of the plasma to over 150 million degrees Celsius, 10 times hotter than the Sun’s core.

    Scientists say that if successful, fusion could offer the world a nearly limitless and clean energy source without the long-lived radioactive waste or carbon emissions of current technologies.

    Thousands of scientists and engineers from member countries have contributed components from hundreds of factories on three continents to build a single machine.

    ITER Director-General Pietro Barabaschi said, “What makes ITER unique is not only its technical complexity but the framework of international cooperation that has sustained it through changing political landscapes.” “This achievement proves that when humanity is faced with existential challenges like climate change and energy security, we can overcome national differences to advance solutions.

    “The ITER Project is the embodiment of hope. With ITER, we show that a sustainable energy future and a peaceful path forward are possible,” he said.

    With more than 10,000 tonnes of superconducting magnets, made from over 1,00,000 kilometres of special wire, ITER represents a global effort to push the boundaries of science and energy technology.

    In 2025, ITER completed the insertion of the first vacuum vessel module into the reactor pit three weeks ahead of schedule. The rest of the components, contributed by different countries, are being assembled piece by piece in what is described as one of the most complex engineering projects ever attempted.

    Private companies are also getting involved. In recent years, there has been a growing interest and investments from the private sector in fusion research.

    ITER has launched new programmes to share knowledge and research data with private players to speed up innovation and development of future fusion reactors.

    Under the current plans, ITER will not produce electricity itself but will serve as a large research facility to test the fusion process at scale. The data generated is expected to help build future commercial fusion power plants.

    As the host of the project, Europe is bearing 45 per cent of the construction cost. The other six members — India, China, Japan, South Korea, Russia and the US — are each contributing about 9 per cent. But all members will get full access to the research results and patents.

    source/content: thehindu.com (headline edited)

    Aurobindo arm’s biosimilar for breast cancer gets EMA panel nod

    Aurobindo Pharma subsidiary CuraTeQ Biologics’ biosimilar for breast cancer has been recommended for marketing authorisation by the Committee for Medicinal Products for Human Use of the European Medicines Agency (EMA).

    “The CHMP has adopted a positive opinion recommending marketing authorisation of Dazublys (150 mg powder for concentrate for solution for infusion), CuraTeQ Biologics s.r.o. trastuzumab biosimilar, for the treatment of HER2-positive metastatic and early breast cancers,” Aurobindo Pharma said on Saturday.

    The positive opinion is based on demonstrating comprehensive analytical similarity and clinically no meaningful differences between Dazublys and the reference biologic product Herceptin in terms of pharmacokinetics, pharmacodynamics, efficacy, safety, and immunogenicity. Upon European Commission approval that is expected in July, Dazublys will be available for use across EU member states, Aurobindo Pharma Director and CEO Biologics, Vaccines and Peptides Satakarni Makkapati said.

    “This marks our third biosimilar to receive CHMP’s endorsement and the fourth overall in the EU, alongside the approval of Bevqolva (a bevacizumab biosimilar) by the MHRA in November 2024. Biosimilars are playing an important role in improving cancer care, and we remain committed to expanding our biosimilars portfolio,” he said in a release.

    Aurobindo Pharma Vice Chairman and MD Nithyananda Reddy said the company is working towards building biosimilars as one of the core businesses. “By 2030, we are committed to launching at least 10 biosimilars across oncology and immunology therapy segments,” he said.

    On Trastuzumab, which a monoclonal antibody, the company said the biosimilar specifically binds and inhibits the human epidermal growth factor receptor 2 (HER2) protein, which is over-expressed on certain types of solid cancers such as breast and gastric cancer. By binding to the extracellular domain of HER2, trastuzumab disrupts its ability to signal, leading to cell cycle arrest, reduced tumour growth and potentially immune system activation to destroy cancer cells.

    source/content: thehindu.com (headline edited)