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Dassault Aviation partners with Tata Advanced Systems for Rafale fighter fuselage production in India

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Describing it as a significant step forward in strengthening the country’s aerospace manufacturing capabilities and supporting global supply chains, Dassault Aviation said the facility represented a vital investment in India’s aerospace infrastructure.

Dassault Aviation and Tata Advanced Systems Limited have signed four Production Transfer Agreements to manufacture the Rafale fighter aircraft fuselage for India and other global markets.

Describing it as a significant step forward in strengthening the country’s aerospace manufacturing capabilities and supporting global supply chains, Dassault Aviation said the facility represented a vital investment in India’s aerospace infrastructure and would serve as a critical hub for high-precision manufacturing.

Under the agreement, Tata Advanced Systems will set up a production facility in Hyderabad for the manufacture of key structural sections of Rafale, including the lateral shells of the rear fuselage, the complete rear section, the central fuselage, and the front section.

The first fuselage sections are likely to roll off the assembly line in 2028, with the facility expected to deliver up to two complete fuselages per month.

“For the first time, Rafale fuselages will be produced outside France. This is a decisive step in strengthening our supply chain in India. Thanks to the expansion of our local partners, including TASL, one of the major players in the Indian aerospace industry, this supply chain will contribute to the successful ramp-up of the Rafale and, with our support, will meet our quality and competitiveness requirements,” said Eric Trappier, chairman and chief executive officer (CEO) of Dassault Aviation.

Sukaran Singh, CEO and managing director, Tata Advanced Systems Limited, said: “This partnership marks a significant step in India’s aerospace journey. The production of the complete Rafale fuselage in India underscores the deepening trust in Tata Advanced Systems’ capabilities and the strength of our collaboration with Dassault Aviation.”

“It also reflects the remarkable progress India has made in establishing a modern, robust aerospace manufacturing ecosystem that can support global platforms,” he said.

“The signing of these contracts reflects Dassault Aviation’s strong commitment to India’s ‘Make in India’ and AtmaNirbhar initiatives. This partnership aims to strengthen India’s position as a key player in the global aerospace supply chain while supporting its goal of greater economic self-reliance,” said Dassault Aviation.

source/content: thehindu.com (headline edited)

Bound for space: Indian astronaut Shubhanshu Shukla set for SpaceX mission with halwa

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Shukla will be the pilot on the Dragon spacecraft commanded by US astronaut Peggy Whitson with Poland’s Slawosz Uznanski-Wisiniewski and Hungary’s Tibor Kapu as mission specialists on the Axiom Mission 4 (Ax-4) during their 14-day stay on the orbiting laboratory.

Indian Air Force combat pilot Shubhanshu Shukla is set to fly to the International Space Station next week from a US spaceport aboard a SpaceX Dragon spacecraft and become India’s second astronaut since Rakesh Sharma’s 1984 Soyuz mission.

Shukla will be the pilot on the Dragon spacecraft commanded by US astronaut Peggy Whitson with Poland’s Slawosz Uznanski-Wisiniewski and Hungary’s Tibor Kapu as mission specialists on the Axiom Mission 4 (Ax-4) during their 14-day stay on the orbiting laboratory.

A SpaceX Falcon 9 rocket will launch the Ax-4 crew aboard the Dragon from Nasa’s Kennedy Space Centre in Florida on June 10. While aboard the ISS, the Ax-4 astronauts plan to conduct over 60 science experiments, public outreach and technology demonstrations. The launch was earlier set for June 8.

Shukla is a group captain with over 2,000 hours of experience flying multiple combat aircraft.

Shukla is one of four candidate astronauts selected for the Indian Space Research Organisation’s (Isro) Gaganyaan human space flight mission expected to take place in 2027.

“It’s been an amazing journey until now — the best is yet to come,” Shukla said on Tuesday at a countdown-to-launch media conference organised by Axiom Space, a US-based private aerospace company engaged in commercial missions to the ISS and working towards building the first commercial space station.

Shukla and fellow IAF group captain Prasanth Balakrishnan Nair, who’s serving as his designated backup, have been under training for the AX-4 mission since August 2024. All the AX-4 crew have undergone training at Axiom Space, Nasa’s Johnson Space Centre and SpaceX. The training has involved simulations of the launch and docking practice, emergency response drills, space station systems training and scientific payload operations.

“We’re ready to go, we’ve trained for all scenarios, bonded as a team,” said Whitson, who will be commanding her second commercial human spaceflight mission and add to her standing record of 675 days for the longest cumulative time in space by an American astronaut.

Shukla revealed during the media briefing that an air show during his school years and a fascination for fighter jets had drawn him into his career as a combat pilot. “When the opportunity (for an Indian human spaceflight mission) arose in 2018, I instinctively applied,” he said.

Among the seven science experiments Shukla will carry for India, one will examine the impact of microgravity on edible microalgae — a nutrient-rich food source. Another experiment will probe the growth of the organisms called Spirulina, a blue-green algae often described as a “superfood” in space.

Shukla will carry mango nectar, carrot halwa and moong dal halwa to share with his fellow astronauts on the ISS.

The experiments, developed under a tie-up between Isro and India’s department of biotechnology with support from Nasa, are intended to generate data for self-sustaining life support systems for future long-duration space travel.

“From orbit, I hope to speak to students, educators, and members of India’s space industry,” Shukla said, outlining some of the crew’s planned outreach activities from the ISS. Uznanski-Wisiniewsky plans to demonstrate physics experiments to students across Poland.

India’s space agency views the Ax-4 mission as yet another step towards its human spaceflight ambitions.

“The experience and the knowhow from the AX-4 mission is significant to us and will feed into our Gaganyaan programme,” Sudeesh Balan, project director at Isro, had said at a mission overview media briefing earlier this month.

source/content: telegraphindia.com (headline edited)

IISc researchers develop novel nanozyme which prevents excess clotting

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When a blood vessel is injured, specialised blood cells called platelets get activated, and cluster together around the vessel to form protective blood clots. However, when these signals go haywire, oxidative stress and levels of toxic Reactive Oxygen Species (ROS) increase, leading to over-activation of platelets.

Researchers at the Indian Institute of Science (IISc.) have developed an artificial metal-based nanozyme that can potentially be used to clamp down on abnormal blood clotting caused by conditions like pulmonary thromboembolism (PTE).

According to IISc., under normal circumstances, when a blood vessel is injured, specialised blood cells called platelets get activated, and cluster together around the vessel to form protective blood clots.

This process, known as the blood clotting cascade (haemostasis), involves a complex series of protein interactions triggered by signals from physiological agonists (chemicals), such as collagen and thrombin.

However, when these signals go haywire in conditions like PTE or diseases like COVID-19, oxidative stress and levels of toxic Reactive Oxygen Species (ROS) increase, leading to over-activation of platelets. This triggers the formation of excess clots in the blood vessel, contributing to thrombosis, a major cause of morbidity and mortality.

To tackle this challenge, researchers led by G. Mugesh, professor in the Department of Inorganic and Physical Chemistry, have developed nanomaterials that mimic the activity of natural antioxidant enzymes, which scavenge reactive oxidative molecules.

These nanozymes work by controlling ROS levels, thereby preventing the over-activation of platelets that leads to excess clot formation or thrombosis.

The team synthesised redox active nanomaterials of different sizes, shapes, and morphologies via a series of controlled chemical reactions starting from small building blocks. They then isolated platelets from human blood, activated them using physiological agonists, and tested how effectively the different nanozymes could prevent excess platelet aggregation.

The team found that spherical-shaped vanadium pentoxide (V2O5) nanozymes were the most efficient. These materials mimic a natural antioxidant enzyme called glutathione peroxidase to reduce oxidative stress.

“The unique chemistry of the vanadium metal is crucial because the redox reactions that reduce ROS levels are happening on the surface of the vanadium nanomaterial,” said Prof. Mugesh.

The team injected the nanozyme in a mouse model of PTE. They found that it significantly reduced thrombosis and increased the animals’ survival rates. They also observed the weight, behaviour, and blood parameters of the animal for up to five days after injecting the nanozyme, and did not find any toxic effects.

The team now plans to explore the efficacy of the nanozyme in preventing ischemic stroke, which is also caused by clogging of blood vessels.

“We are hopeful about clinical studies in humans because we have done our experiments with human platelets, and they worked,” said Prof. Mugesh.

source/content: thehindu (headline edited)

UoH faculty member elected as Fellow of Royal Society of Chemistry

G.S. Vaitheeswaran from University of Hyderabad’s (UoH) School of Physics has been elected as a Fellow of the prestigious Royal Society of Chemistry for his contributions to understanding the electronic structure of solids, particularly in the field of energetic materials.

The fellowship will enable Prof Vaitheeswaran to expand his research network and collaborations with universities worldwide, facilitating international funding and participation in conferences.

He has received several notable awards, including the DAE Young Achiever Award, B.M. Birla Science Prize in Physics, and the Chancellor Award for Excellence in Teaching and Research, as per a press release on Friday (May 1, 2025).

source/content: thehindu.com (headline edited)

Aurobindo arm’s biosimilar for breast cancer gets EMA panel nod

Aurobindo Pharma subsidiary CuraTeQ Biologics’ biosimilar for breast cancer has been recommended for marketing authorisation by the Committee for Medicinal Products for Human Use of the European Medicines Agency (EMA).

“The CHMP has adopted a positive opinion recommending marketing authorisation of Dazublys (150 mg powder for concentrate for solution for infusion), CuraTeQ Biologics s.r.o. trastuzumab biosimilar, for the treatment of HER2-positive metastatic and early breast cancers,” Aurobindo Pharma said on Saturday.

The positive opinion is based on demonstrating comprehensive analytical similarity and clinically no meaningful differences between Dazublys and the reference biologic product Herceptin in terms of pharmacokinetics, pharmacodynamics, efficacy, safety, and immunogenicity. Upon European Commission approval that is expected in July, Dazublys will be available for use across EU member states, Aurobindo Pharma Director and CEO Biologics, Vaccines and Peptides Satakarni Makkapati said.

“This marks our third biosimilar to receive CHMP’s endorsement and the fourth overall in the EU, alongside the approval of Bevqolva (a bevacizumab biosimilar) by the MHRA in November 2024. Biosimilars are playing an important role in improving cancer care, and we remain committed to expanding our biosimilars portfolio,” he said in a release.

Aurobindo Pharma Vice Chairman and MD Nithyananda Reddy said the company is working towards building biosimilars as one of the core businesses. “By 2030, we are committed to launching at least 10 biosimilars across oncology and immunology therapy segments,” he said.

On Trastuzumab, which a monoclonal antibody, the company said the biosimilar specifically binds and inhibits the human epidermal growth factor receptor 2 (HER2) protein, which is over-expressed on certain types of solid cancers such as breast and gastric cancer. By binding to the extracellular domain of HER2, trastuzumab disrupts its ability to signal, leading to cell cycle arrest, reduced tumour growth and potentially immune system activation to destroy cancer cells.

source/content: thehindu.com (headline edited)

India’s Gongadi Trisha scripts history; becomes first centurion in the history of Women’s U19 T20 World Cup

Right-handed batter Gongadi Trisha scripted history as she became the first centurion in the history of Women’s U19 T20 World Cup. 

Right-handed batter Gongadi Trisha scripted history as she became the first centurion in the history of Women’s U19 T20 World Cup. On Tuesday, the youngster smashed a ton off just 53 balls in India’s Super Six clash against Scotland at the Bayuemas Oval in Kuala Lumpur.

She eventually remained unbeaten on 110 off just 59 balls. Her innings was studded with 13 fours and 4 sixes. She and Sanika Chalke powered India to a commanding total of 208/1 in the allotted twenty overs.

Earlier, Scotland had won the toss and opted to field. India openers Kamalini G and Trisha Gongadi started the innings with a bang, hitting boundaries constantly. The duo put on 67 runs in the powerplay.

The opening batters put on a stand of 147 runs for the first wicket. Kamalini eventually lost her wicket in the 14th over of the innings as she walked back to the hut after scoring 51 off 42 balls.

The opening stand of 147 runs is the highest partnership for any wicket in the ongoing Women’s U19 T20 World Cup.

Sanika Chalke also remained unbeaten on 29 as India posted more than 200 runs on the board.

India register a commanding 150-run win

Aayushi Shukla, Vaishnavi Sharma and Gongadi Trisha took all the ten wickets between themselves to bundle out Scotland for 58 inside 14 overs.

Aayushi took four wickets, while Vaishnavi and Trisha took three wickets each. For Scotland, opening batters Pippy Kelly and Emma Walsingham were the only ones who seemed cut out to handle the pressure situation.

The rest of the batters collapsed in quick succession, and India ultimately registered a comprehensive win. Gongadi Trisha was adjudged as Player of the Match for her perfect all-round effort.

India have already qualified for the semi-finals and the defending champions will play their semi-final on Friday, January 31.

The final of the tournament is scheduled for Sunday, February 2.

source/content: hindustantimes.com / Crickit by HT (headline edited)

Oscars 2025: Payal Kapadia’s seat at the big table

A lack of budget certainly didn’t stop the filmmaker. Her big win at Cannes, along with rave reviews, special screenings and strong distributors with festival know-how have given her an edge.

In the spring of 2022, S.S. Rajamouli’s historical action drama RRR was a huge hit in India and in the global Indian diaspora market when two American distributors floated the idea of releasing it once again — to reach an audience not usually drawn to Indian films.

With great word of mouth and reviews, the film pulled more American audiences. It was quite unlike anything Americans had seen. RRR ended up winning a few critics’ association awards and a Golden Globe for the song ‘Nattu Nattu’. One day before the final Oscars voting began, the distributors, Variance Films and Potentate Films, organised a sold-out screening in the 1,647-seat Ace Hotel Theatre in Los Angeles. A couple of weeks later, ‘Nattu Nattu’ won an Oscar for Best Achievement in Music Written for Motion Pictures.

Indian films rarely make such an impact in the U.S. during the awards seasons. I have been observing this for over four decades, first as a journalism student, then an entertainment writer and the festival director of the oldest Indian film festival in North America. Unless it is a work of the magnitude of Richard Attenborough’s Gandhi — a British-Indian co-production that won eight Oscars in 1983, beating Steven Spielberg’s most loved film E.T., the Extra-Terrestrial. Danny Boyle’s Slumdog Millionaire also won eight Oscars, but unlike Gandhi it was a British production with no Indian producer attached to it.

Grand Prix sets the ball rolling

Marketing, promotion, and celebrity endorsements are often a big part of the awards campaign. In the fall of 2001, British filmmaker Roland Joffé (The Killing Fields) called a few of his friends in Hollywood — all members of the Academy of Motion Picture Arts and Sciences. Joffé had seen Ashutosh Gowarikar’s Lagaan, which was India’s entry for the Best Foreign Language Film. He had liked the film — about a farmer during the British Raj who challenges its officers to a game of cricket to get tax exemption — and wanted to make sure his friends would attend the Academy’s screening.

But in all these years I had not seen an Indian film reach American shores with a stamp of having won an award at a major film festival — not until May 2024, when Payal Kapadia’s second feature All We Imagine as Light won the Grand Prix at the 77th Cannes Film Festival. It was the first Indian film in 30 years to play in the main competition section of the festival.

Suddenly, it seemed everyone was talking about All We Imagine as Light, a Malayalam language drama on three working women and the transformative power of friendship and sisterhood. IndieWire gave it an A rating; they are usually very conservative in their reviews. And senior critic Peter Bradshaw of The Guardian gave the film a five-star rating, comparing it to Satyajit Ray’s Mahanagar and Aranyer Din Ratri.

his followed screenings at the top three fall season festivals in North America: Telluride, Toronto and New York. There were more awards, including from several American critics’ associations. And even though India did not submit All We Imagine as Light for the Academy Award for Best International Feature Film, the buzz about it remained strong.

According to filmmaker and film preservationist Shivendra Singh Dungarpur the reason for the success of All We Imagine as Light is the new film language that Kapadia has developed. “She blends fiction with documentary style of filmmaking giving her narrative an almost hypnotic quality,” he says. “You can’t tell where the fiction begins and when it is pure documentary.” Mumbai-based Kapadia worked as an assistant with Dungarpur before she joined the Film and Television Institute of India (FTII). Her journey since has been one of resilience — overcoming wrongful charges of rioting at FTII (where her scholarship was suspended), to persisting with her vision even when her films never found a local audience. Until now.

Under a Golden spotlight

One of the advantages All We Imagine as Light could have had is its European producers. “I don’t know [if there’s a specific] benefit in having a producer from a different part of the world… but if you are keen to premiere at a film festival in Europe, then European producers know the process,” says Kapadia. “Now, many Indian producers are learning about it, along with the American festival system. Look at Reema Das. She is her own producer and has always premiered her movies at top-level festivals. Her films are very local and yet the themes resonate across the world.”

Late last year, several critics and major publications — from The New York Times to Sight and Sound magazine ranked All We Imagine as Light as the number one film of the year. In its recent Instagram post, Sight and Sound described the film as “a delicate, dreamlike tale of loneliness and fellowship” and added that the film recalled works of Ray and Wong Kar-wai. One day after Christmas, Variety named Kapadia as one of the international breakouts of the year.

So, no one seemed surprised when All We Imagine as Light received two Golden Globes nominations, including one in the Best Director category. Variety wrote this reflected “Kapadia’s growing influence in world cinema”. This was the first such nomination for an Indian filmmaker for a film made in India. In 1999, Shekhar Kapur received a Best Director nomination for Elizabeth, but that was a British production.

All We Imagine as Light also received a Golden Globes nomination for Best Motion Picture – Non-English Language. The Academy of Motion Picture Arts and Sciences only accepts one international film submitted by each individual country, but the Hollywood Foreign Press Association — the body that awards the Golden Globes — accepts submissions by producers of foreign language films. And so the filmcould compete.

For a while now, commentators have said that the Golden Globes have lost their significance. But one cannot deny that Academy members and studios seriously follow the Globes — the nominations and the awards. (And since any film that runs for a week in any of the U.S.’s six metropolitan areas is eligible to be nominated for the Oscars, All We Imagine as Light is a contender.)

Kapadia attended the Globes dressed in a black silk outfit designed by Payal Khandwala and she wore earrings gifted to her by her mother, the painter Nalini Malani. She was accompanied by her two French producers, Thomas Hakim and Julien Graff, and cinematographer Ranabir Das. “It was such a huge honour to be nominated,” Kapadia shares the day after the Golden Globes ceremony. “The nominations really put our film back in people’s attention. And of course, talking to stars you have admired is always a thrill. I met Jodie Foster as well as director Walter Salles who had both seen our movie, and they liked it!”

Kapadia’s chance of winning a Globe was never definite, given the competitive field she was in, but her name has already registered in the minds of many Academy members. Meanwhile, last week, the film was longlisted in three categories for the British Academy Film Awards (BAFTA), including best director.

Celebrity support for Indian films 

The torch of All We Imagine as Light has been kept burning by the film’s two distributors, Janus Films and Sideshow. The former had two other foreign language films nominated for the Golden Globes: Vermiglio (Italy), a drama set during World War II, and Flow (Lithuania), a fantasy adventure about a solitary cat’s survival. Flow won the Globe for the Best Motion Picture, Animated.

“We are lucky to work with Janus and Sideshow who really take care of the films they distribute,” Kapadia says. “They understand this system well and make sure that the campaign effort is streamlined and specific. We don’t have a major studio funding backing this effort so it’s sheer hard work from everyone involved.” A stark contrast to money-backed films such as RRR or even a Gandhi, which had the support of a big studio for its Oscar campaign.

But in a crowded field with Hollywood and foreign language films competing for the short attention span of Academy members, celebrity support for films can be really helpful. Late last year before the Oscar shortlists were announced, Mexican filmmaker Alfonso Cuarón hosted a screening of Kiran Rao’s Laapataa Ladies in London. British film director of Indian origin Gurinder Chadha, who is a member of the Academy along with Cuarón, also attended the screening.

In mid-November, Indian-American filmmaker Mira Nair moderated a post-screening Q&A of All We Imagine as Light with Kapadia at NeueHouse, a small theatre in Manhattan with just 86 seats. The screening was organised by Janus Films and Sideshow to generate interest before the limited release of the film on November 15 in New York City. But it was also intended to start the buzz among Academy members based in the city. The NeueHouse screening was attended by a few Indian-American Academy members, including publicist Gitesh Pandya and producer Shrihari Sathe. Nair is also an influential member of the Academy.

The same evening, Netflix hosted a screening of Laapataa Ladies in New York City. At the time, the film was in consideration for the Best International Feature Film award. Kiran Rao and Aamir Khan were present as was Nair, who did a Q&A with the director and producer. Nair then rushed to moderate the NeueHouse Q&A of All We Imagine as Light. She had seen Kapadia’s film earlier.

Is another nomination likely?

These special screenings by well-known filmmakers are held throughout the awards seasons. In December, Kapadia was interviewed by director Shuchi Talati (Girls Will Be Girls) after the film’s screening at Film Forum, a prime art-house theatre in New York City. Again, the Q&A was meant to create a buzz about All We Imagine as Light as the Academy members were getting set to watch the films in consideration. The film is now in its eighth week of theatrical run at Film Forum.

And earlier at the end of October, Kapadia was in Japan for the Tokyo International Film Festival when she had an in-depth conversation with the Japanese master Hirokazu Kore-eda. (Kore-eda received a Palm d’Or at the Cannes Film Festival in 2018 for Shoplifters. The next year Shoplifters received an Academy Award nomination for the Best Foreign Language Film.)

During the conversation, Kore-eda asked Kapadia her thoughts on All We Imagine as Light not being sent to the Academy Awards. Her response was measured and diplomatic. “I think with this film, it got a lot already. I’m very satisfied with how the journey of the film has gone. And it’s been really more than I expected. So everything that comes its way, it’s like a bonus for me.”

All We Imagine as Light has had a huge success in finding distribution deals in 85 countries. And according to Zico Maitra, one of the film’s producers, it has already opened in 43 countries, including just recently in the U.K., Germany and Spain. After a limited release in India, the film is also streaming on Disney+Hotstar. Kapadia wanted her film to be seen by people across the country. Hence, the screenings took place in major cities, but also those that could be described as Tier-II cities: Guwahati, Chandigarh and Kanpur. The OTT release is a part of the extra bonus Kapadia mentioned.

Voting for the Academy Awards is on from January 8 to 12, and the nominations will be announced on January 19. While no one can predict whether All We Imagine as Light will receive any nominations, this much is clear: Kapadia and her film already have a seat at the main dinner table. She will be there even after the award season has ended.

The writer is a film festival programmer and author.

content/source: thehindu.com (headline edited)

IIT-Guwahati develops advanced nanotechnology for cholesterol, triglyceride detection

The institute claims that their researchers have focused on a technique that combines nanotechnology and molecular detection, which can further be translated into a point-of-care as device with an enhanced diagnostic precision.

Researchers at Indian Institute of Technology (IIT), Guwahati have developed an innovative approach to improve the detection of cholesterol and triglycerides by integrating Surface-Enhanced Raman Scattering (SERS) on the nanoscale objects, officials said.

The findings of the research were recently published in the noted journal –Biosensors and Bioelectronics.

According to Dipankar Bandyopadhyay, Professor at Centre for Nanotechnology and Department of Chemical Engineering, IIT-Guwahati, the work utilises bimetallic nanostructures that are 10,000 times thinner than the width of a human hair for the high-fidelity detection of the biomarkers in the human blood.

“The metabolic biomolecules like cholesterol and triglycerides play pivotal role in maintaining a harmonious cardiovascular health of a human body. The high (HDL) and low (LDL) density lipoproteins transport cholesterol to the cellular sites for various metabolic activities,” he said.

Bandyopadhyay explained an imbalance of LDL and HDL causes arterial plaque formation leading to hypertension, formation of blood clots, or ischemia.

On the other hand, triglycerides (TGA) transform into fatty acids and glycerol during digestion which in turn is packaged inside lipoproteins namely very low-density lipoprotein (VLDL), for transportation to the cells. An elevated level of triglycerides leads to atherosclerosis and coronary artery disease, pancreatitis, type 2 diabetes, or fatty liver, he said.

“Therefore, the timely detection of any abnormality and a close monitoring of cholesterol and triglyceride levels in blood is highly sought for. While traditional lipid profile tests of blood are reliable, they often require laboratory settings, are not available as a point-of-care solution, and can take time to provide results,” he said.

IIT-Guwahati claimed that their researchers have focused on a technique that combines nanotechnology and molecular detection, which can further be translated into a point-of-care as device with an enhanced diagnostic precision.

“The researchers employ SERS active bimetallic nanostructures – the silver shelled gold nanorods, which enable a plasmonic resonance hybridisation of silver and gold to produce augmented spectral resolutions as compared to pristine silver or gold nanorods.

“Subsequently, these bimetallic nanorods are linked to two different Raman active receptors and immobilised with the enzymes cholesterol oxidase and lipase for concurrent detection of different concentrations of cholesterol and triglycerides. Such innovations help in the development of a platform for the ultrafast point-of-care detection kit with a higher level of the detection sensitivity,” Bandyopadhyay said.

Except for the headline, this story has not been edited by The Telegraph Online staff and has been published from a syndicated feed.

source/content: telegraphindia.com (headline edited)


INSV Tarini with two woman Navy officers begins third leg of circumnavigation

Woman Navy officers Lt Cdr Dilna K. and Lt Cdr Roopa A began the journey on October 2, 2024 from Lyttelton Port in New Zealand to Port Stanley in Falkland Islands, the longest leg of the expedition with a distance of approximately 10,400 km to cover.

Indian Naval Sailing Vessel (INSV) Tarini left Lyttelton Port in New Zealand on Saturday (January 4, 2025) morning at about 9. 30 a.m. local time for Port Stanley (Falkland Islands) in the third leg of the ongoing global circumnavigation journey by two woman Navy officers under Navika Sagar Parikrama-II.

This is the longest leg of the expedition with a distance of approximately 5,600 nm (approximately 10,400 km) to cover. This will also be the southernmost transit of Tarini at about 56 degrees South, the Navy said in a statement. “With the frontal weather systems of the Southern Ocean, Team Tarini can expect to experience challenging seas with up to 50-60 knots (90-110 kmph) winds.”

INSV Tarini had arrived in Lyttelton on December 22, completing the second leg of the double-handed circumnavigation, which is being undertaken by two Indian Navy women officers — Lt Cdr Dilna K. and Lt Cdr Roopa A.

“During the period in Lyttelton, the crew undertook repairs and maintenance of the boat with particular focus on the next leg where the vessel will cross the South Pacific, pass through the treacherous Drake Passage, and cross Cape Horn to reach Port Stanley,” the Navy said. “While in Lyttelton, the crew also interacted with the Indian community who were eager to visit the boat and query the crew about various aspects of ocean sailing.”

INSV Tarini was open to visitors at Lyttelton Port of Christchurch (LPC) on Thursday (January 2, 2025). People from different walks of life, including Victoria Henstock, the councillor of Christchurch City Council, visited the vessel and interacted with the crew.

Maori payers for the crew

Members of the Indian diaspora as well as Belfiore Bologna, Honorary Consul of Italy for the South Island of New Zealand and Sue McFarlane, Head of Christchurch Antarctic Office turned up for the Flag Off ceremony of the vessel. Traditional Maori prayers for the crew by members of the Maori community were also undertaken during the ceremony.

The expedition was flagged off from Goa on October 02, 2024 by Navy Chief Adm Dinesh K. Tripathi. After sailing across the Indian Ocean for 38 days, INSV Tarini halted at Fremantle, Australia, from November 9 to 24, and the second leg from Fremantle to Lyttelton was covered in 28 days.

The circumnavigation will cover around 23,000 nautical miles in around 240 days, across four continents through three oceans and three challenging Capes, unfolding in five legs with stopovers at four ports for replenishment and maintenance. The five legs are Goa to Fremantle, Australia; Fremantle to Lyttleton, New Zealand; Lyttleton to Port Stanley, Falkland Islands; Port Stanley to Cape Town, South Africa; and from Cape Town back to Goa.

INSV Tarini, a 56-foot sailing vessel built by Aquarius Shipyard Ltd, was inducted in the Indian Navy on February 18, 2017. The vessel has clocked more than 66,000 nautical miles (1,22,223 km) and participated in the first edition of Navika Sagar Parikrama in 2017, trans-oceanic expedition from Goa to Rio, Goa to Port Louis and other significant expeditions. Both the officers with a sailing experience of 38,000 nautical miles (70,376km) trained vigorously in the last three years.

source/content: thehindu.com (headline edited)

Researchers from the Indian Institute of Technology Guwahati and the Bose Institute Kolkata have developed an advanced injectable hydrogel for localised cancer treatment.

This innovative hydrogel-based therapy delivers anti-cancer drugs directly to tumour sites, reducing side effects associated with cancer treatments.

Researchers from the Indian Institute of Technology Guwahati and the Bose Institute Kolkata have developed an advanced injectable hydrogel for localised cancer treatment.

This innovative hydrogel-based therapy delivers anti-cancer drugs directly to tumour sites, significantly reducing side effects typically associated with conventional cancer treatments.

The findings have been published in the “Materials Horizons”, a journal of the Royal Society of Chemistry. The paper is co-authored by Prof Debapratim Das, along with research scholars Tanushree Das and Ritvika Kushwaha from IIT Guwahati. The collaborators are Dr Kuldip Jana, Satyajit Halder and Anup Kumar Misra from the Bose Institute Kolkata.

“Cancer continues to be a pressing global health challenge, with millions of patients affected worldwide. Current treatments, such as chemotherapy and surgical interventions, often have severe limitations. Surgical removal of tumors is sometimes not feasible, particularly for internal organs, while chemotherapy’s systemic delivery often results in harmful side effects by affecting both cancerous and healthy cells,” the IIT Guwahati said in a statement.

Prof Das from the Department of Chemistry and his team addressed these challenges by designing a hydrogel that delivers drugs precisely to the tumour site, ensuring localised action.

Hydrogels are water-based, three-dimensional polymer networks capable of absorbing and retaining fluids. Their unique structure mimics living tissues, making them suitable for biomedical applications. This newly developed hydrogel acts as a stable reservoir for anti-cancer drugs and releases them in a controlled manner, responding to specific conditions in the tumour microenvironment.

The hydrogel, composed of ultra-short peptides – biocompatible and biodegradable building blocks of proteins – is designed to remain insoluble in biological fluids, ensuring it stays localized at the injection site. It responds to elevated glutathione (GSH) levels, a molecule abundant in tumour cells. Upon encountering high GSH levels, the hydrogel triggers a controlled drug release directly into the tumour, minimizing its interaction with healthy tissues and reducing systemic side effects.

Speaking about the breakthrough, Prof Das said, “This work exemplifies how scientific innovation can directly address the pressing needs of cancer treatment. The hydrogel’s unique properties allow it to work in harmony with the biological environment, offering precision where it is needed most. We are excited by its potential to transform our thoughts about localized drug delivery.”

In pre-clinical trials on a murine model of breast cancer, the hydrogel showcased remarkable efficacy. A single injection of the hydrogel, loaded with the chemotherapy drug doxorubicin, resulted in a 75% reduction in tumour size within 18 days. Crucially, the hydrogel remained localized at the tumour site, steadily releasing the drug over time without causing detectable side effects on other organs, the IIT Guwahati said.

“This innovative delivery system enhances the drug’s effectiveness while reducing the required dosage, thus minimizing toxicity. Laboratory studies further demonstrated that the hydrogel improves drug uptake by cancer cells, induces cell cycle arrest, and promotes programmed cell death, thereby attacking tumours on multiple fronts,” the institute further stated.

source/content: newindianexpress.com (headline edited)