Research for developing artificial limb is funded by Union ministry of education and the department of biotechnology.

Researchers at the Indian Institute of Technology Guwahati (IITG) have developed an affordable prosthetic leg with advanced features, specifically designed for Indian conditions.

The IIT Guwahati said on Monday that the artificial limb allows its user to sit cross-legged and squat deep and is suitable for uneven terrain.

“Affordable prosthetics that are available in the market have many functional limitations. In addition, the Indian lifestyle and uneven terrain require prosthetics with specifications unique to India, which are not widely available in the market. The leg developed by us is state-of-the-art technology, affordable, light weight, stable and capable of mimicking most of the human joint’s motion, the IIT-G said, adding cost of around Rs 25,000 is ensured using the technology.

IIT Guwahati researchers collaborated with 151 Army Base Hospital, Guwahati, Tolaram Bafna Kamrup District Civil Hospital, Guwahati Neurological Research Centre (GNRC), North Guwahati, and North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGHRIMS), Shillong, to develop the leg.

A team led by professor S. Kanagaraj, department of mechanical Engineering, IITG, set out to tackle these issues. Prototypes of their models developed by this research team are currently undergoing trials.

Professor Bhaskar Borgohain, head of department (Orthopaedic) at NEIGHRIMS told The Telegraph that work on the project started in 2013 with the objective of developing a “user-friendly and light weight” limb.

He has been associated with the project from the beginning.

“The legs developed by us will not only help cut down on imports of prosthetic legs, especially from Germany and UK, but will also be a huge relief to those in need of such legs. An imported artificial limb will cost anywhere between Rs 1.5 lakh and Rs 3.5 lakh. Our legs would cost much less. It will be launched soon,” Borgohain said.

source/content: telegraphindia.com (headline edited)

The mini proteins can not only block the entry of viruses like SARS-CoV-2 into our cells but also clump virus particles together, reducing their ability to infect.

Researchers at the Indian Institute of Science (IISc) Bangalore have designed a new class of artificial peptides or mini proteins that they say can render viruses like SARS-CoV-2 inactive.

According to the study, published in the journal Nature Chemical Biology, the mini proteins can not only block virus entry into our cells but also clump virus particles together, reducing their ability to infect.

The researchers noted that protein-protein interaction is often like that of a lock and a key.

Preventing entry

The team used this approach to design mini proteins that can bind to, and block the spike protein on the surface of the SARS-CoV-2 virus, which helps it to enter and infect the human cells.

This binding was further characterised extensively by cryo-electron microscopy (cryo-EM) and other biophysical methods.

These mini proteins are helical, hairpin-shaped peptides, each capable of pairing up with another of its kind, forming what is known as a dimer. Each dimeric ‘bundle’ presents two ‘faces’ to interact with two target molecules.

The researchers hypothesised that the two faces would bind to two separate target proteins locking all four in a complex and blocking the targets’ action.

“But we needed proof of principle,” said Jayanta Chatterjee, Associate Professor in the Molecular Biophysics Unit (MBU), IISc, and the lead author of the study.

source/content: thehindu.com (headline edited)